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Microdosing with LSD Versus Psilocybin


Microdosing with psychedelics is gaining in popularity for various reasons. Some are using them in order to open their minds, to think more broadly and creatively, and become less rigid—whether when working, creating, or just going about their day-to-day. Others are microdosing to alleviate symptoms of mental health issues such as depression, anxiety, OCD, and/or PTSD. It is a more holistic approach to dealing with negative internalizations—and sometimes along with talk therapy or other forms of treatment, psychedelic microdosing is being used more frequently than in the past.


Some states are now in the process of considering decriminalizing possession of psychedelics and approving the therapeutic use of them. Oregon is one state who already has approved them for use in these ways by passing Measure 109 and Measure 110.


The psychedelics chosen for microdosing purposes are LSD (acid) and psilocybin (mushrooms). Microdosing on these have the following effects on many individuals:


  • Enhances performance

  • Induces a positive mood

  • Increases focus and concentration

  • Enhances creativity

  • Alleviates psychological symptoms

  • Satiates curiosity

But why choose one over the other? What is the difference between microdosing on LSD versus psilocybin?


Understand that there are many similarities in the way mushrooms and LSD work within the brain and the effects they cause; however, there are many differences in how they are made, obtained, taken, and how you feel afterward.



Microdosing LSD

  • LSD was made illegal in the UK and US in the late 60s.

  • LSD is synthetically created in a laboratory.

  • LSD can be microdosed by cutting up a tab to whatever dose you need.

  • Acquiring LSD depends on the legality of the substance where you live.

  • Anecdotal reports say that microdosing withLSD is like you’re taking “something designed to improve you.”

  • The location best to microdose with LSD is in a “busy, populated environment” where you may be socializing and getting things done.

Microdosing Psilocybin

  • Mushrooms were made illegal in the US by 1970.

  • Psilocybin is created organically by nature.

  • Psilocybin can be microdosed by grinding up the dried mushrooms into a powder, and then weighing on a special scale and then separating the powder out into capsules—a little more work than LSD.

  • Acquiring psilocybin depends on the legality as well—many places still ban these truffles.

  • Anecdotal reports say that microdosing with psilocybin is like your ego is being dissolved “by immersing the user in their surroundings.”

  • The location best to microdose with psilocybin is when you have an “open day and open space, and are seeking some introspection and solitude.”


Ultimately, choosing one over the other really just depends on your personal preference and where and how you can obtain the substance. They both have similar effects, yet as you can see, they work a little bit different depending on the environment you want to be in when dosing.


Either way—have fun and be safe!

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